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Study: Inhaled Cannabis Mitigates Parkinson’s Disease Symptoms


Inhaling whole-plant cannabis provides symptomatic relief in patients with Parkinson’s disease (PD),

according to observational trial data published in the March/April edition of the journal Clinical Neuropharmacology.

Parkinson’s is a progressive disorder of the central nervous system that results in tremor, slowed movement, and muscle rigidity.






The Science of Chocolate and Cannabis: How They Combine To Make Powerful Medicines


Chocolate and cannabis are so wonderful that even the mention of both in a sentence is enough to make one giggle. Scientific proof is mounting that both chocolate and cannabis contain healing properties. Their dance is well-known to many, who may have fond memories of gorging through a pan of pot brownies. Indeed, these two super foods are magical & below there is plenty of science that answers ‘how’ and ‘why’ they work so well as medicine.



Cannabinoids are fat-soluble (lipophilic), often-medicinal, chemical compounds found in plants and mammals. These compounds can also be synthetically manufactured. The most well-known natural cannabinoid chemical is Delta-9-tetrahydrocannabinol (THC). THC, as we know, is the primary psychoactive compound found in the cannabis genus of plants. Currently there are approximately 85 different cannabinoids that have been isolated from cannabis including the known medicinal compound cannabidiol (CBD). Of cannabis’s cannabinoid extracts, CBD is second in concentration only to THC, ranging as high as 40%.

The search for more cannabinoids in plants took an interesting turn in 1996 when Daniele Piomelli and fellow researchers isolated a cannabinoid neurotransmitter called anandamide (n-arachidonoylethanolamine or AEA) in chocolate. The interesting thing about anandamide is that it is also a naturally endogenous (internally occurring) cannabinoid found in the human brain and nervous system that plays a role in feelings of overall well-being.


The word “anandamide” means “the bliss chemical” because it is released while we are feeling great. Anandamide is derived from the Sanskrit word “ananda” meaning bliss and “mide” meaning chemical.


Cannabinoid Receptors

The original discovery of anandamide in the early 1990s and its discovery in chocolate arose from research into cannabinoid receptor sites. A receptor site is a structure on the surface of a cell that can lock onto certain molecules, making it possible to carry a signal through the cell wall — a “lock-and-key” system. It had long been known that the human brain contains receptor sites that interact with cannabis’ THC molecule. It was inevitable that an endogenous, naturally-occurring, chemical — namely: anandamide — would be found to explain the presence of these receptors.

Cannabinoids such as THC, CBD, and anandamide are keys that fit into (or agonize) cannabinoid receptor sites (or locks) in mammals. Agonists are chemicals that bind to particular receptors on cell membranes (in this case, cannabinoid receptors) and that subsequently trigger responses by these cells. For example, THC agonizes cannabinoid receptors throughout the human body causing not only the classic marijuana high, but also medicinal effects that could protect certain cells and/or cause mutated cells to be destroyed by the immune system. In another example, anandamide in chocolate agonizes cannabinoid receptors throughout the human body. Because anandamide is slightly chemically different from THC, it causes slightly different effects. Eating chocolate provides a mild high, weaker (though similar) to the classic marijuana high. Chocolate’s anandamide also influences cells that affect mood, memory, appetite, pain perception, and (overall) may in fact provide medicinal benefits similar to THC.


There are currently two known main subtypes of cannabinoid receptors: CB1 and CB2 — with a third group CB3 still being researched. The CB1 group of cannabinoid receptors is found mainly in the brain (central nervous system), but also in the kidneys, liver, and lungs. The CB2 group of cannabinoid receptors is found mainly amongst the immune system’s cells (T and B cells, macrophages) and in hematopoietic cells (stem cells that give rise to red blood cells).



Medicinal Benefits of Cannabinoids

It is of interesting note that the CB2 group of cannabinoid receptors are found amongst immune cells. This discovery has now validated that cannabinoids function to modulate immunity providing overt medicinal benefits. Scientific research indicates that cannabinoids may protect: the gastrointestinal tract (reducing: inflammatory bowel disease, ulcerative colitis, Crohn’s disease); the heart; from pain; bone density; as well as even greater benefits against metabolic plaque formation (calcification) and even cancer.



THC is a well-known, extraordinarily well-studied, pre-eminent anti-emetic, anti-nausea, and pain relief agent.

As a CB2 cannabinoid receptor site agonist THC is effective not only in the treatment of pain, it is also effective against numerous inflammatory conditions, osteoporosis, and atherosclerosis in different animal studies.

Activation of CB1 by THC provides neuro-protection after a brain injury. THC is also effective against certain forms of migraine headaches.

Although not conclusively proven to be curative of multiple sclerosis, THC has been shown to alleviate muscle stiffness and pain associated with multiple sclerosis.

Glaucoma is the second leading cause of blindness. THC is able to lower internal eye pressure and improve eyesight in those suffering from glaucoma.

Rick Simpson’s film “Run From The Cure” indicates that cannabis oils (including and especially THC) can cure surface skin cancers and treat other types of cancers as well. We have personally seen the positive (often miraculous) effects of cannabis oils on skin cancers in half a dozen people. Experience in the healing profession has also indicated to us that Dr. William Courtney’s testimony of using raw cannabis leaf juice to treat cancer in his patients is accurate and effective.

Some types of tumors, especially gliomas, possess CB2 cannabinoid receptors. THC and WIN-55,212-2 (a potent cannabinoid agonist similar to THC in effect, yet totally different in structure), cause the regression or eradication of malignant brain tumors in rats and mice.

In addition to these benefits, THC is psychoactive, allowing for stress-relief, activation of the imagination, increase in musical sensitivities, release from material concerns, and reconnection with the natural environment.



Mental Health: More research continues to pile up indicating that CBD is neuroprotective and acts as an anti-psychotic and anti-schizophrenic medication that also counteracts the possible delusional and hallucinatory effects of THC on those with a history schizophrenic symptoms. In a similar way, CBD may actually counteract social anxiety disorders including paranoia that may be triggered or exacerbated by THC.

Cancer: Like THC, CBD’s show efficacy against glioma cell lines (brain or spinal tumors formed of glial cells). CBD turns off DNA-binding protein inhibitor ID-1. This protein inhibitor is considered responsible for tumor metastasis, especially in breast cancer. CBD may act to cause apoptosis in cancer cells (the spontaneous self-destruction of these cells) via its action on mutant p53 proteins found in cancer cells.

Cannabis samples containing higher fractions of cannabidiol (as opposed to THC) are known to allay the short-term memory loss associated with cannabis use.

Overall CBD has the following properties: anti-inflammatory, antioxidant, anti-depressant, antibiotic, anti-ischemic, immunomodulatory, anti-tumor, and shows promise as an anti-arthritic and anti-metastatic compound.

All of these benefits indicate the future will deliver more CBD-rich strains of cannabis.




Anandamide’s effects can be either levied upon the central nervous system (e.g. brain, nerves, etc.) or peripheral, in cells throughout the body (e.g. white blood cells). The latter, as we have seen, are mainly involved in functions of the immune system.

High levels of anandamide were found in young men who ran or cycled at a moderate rate for about an hour, according to a study published in the journal NeuroReport by the Georgia Institute of Technology and the University of California, Irvine. Anandamide may be responsible for the euphoric feeling some people experience when they exercise that we sometimes call “runner’s high.” Arne Dietrich, the study’s principal investigator believes the body releases cannabinoids to help cope with the prolonged stress and pain of moderate or intense exercise. Studies have linked anandamide to analgesic reactions produced by the body during exercise, especially by running.

Anandamide is also an activator of the transient receptor potential (TRP) vanilloid 1 (TRPV1) found on primary sensory neurons. The activation of the TRPV1 receptor activates a metabolic anti-inflammatory response.

Going beyond just anti-inflammatory action, anandamide is known to inhibit human breast cancer cell proliferation.

Anandamide plays a role in eating habits and appetite and in the generation of both: motivation and pleasure. Experiments indicate that anandamide may be as important as the more well-known neurotransmitters: dopamine and serotonin. Anandamide may act as a component in the control of cognition and expression of emotions. Anandamide, when injected directly into the forebrain of rats, enhances their pleasurable responses to sucrose rewards, and increases their food intake as well.


The Coup De Grace: How Chocolate Increases the Power of THC and CBD

Not only does chocolate contain anandamide, it also contains, in much higher amounts than anandamide (by a factor of 103-104), the cannabinoid breakdown inhibitors: N-oleolethanolamine (OEA), a known inhibitor of weight gain in mice, and N-linoleoylethanolamine (18:3 NAE), a known anti-inflammatory molecule — like anandamide — via the TRPV1 receptor). These two structural cousins of anandamide both inhibit the metabolic breakdown of anandamide and could potentially inhibit the breakdown of other cannabinoids including THC and CBD causing these compounds to stick around longer, providing even more benefits (as if one had taken more THC or CBD).

Theobromine, the major xanthine alkaloid and caffeine-relative in chocolate, is a known vasodilator that acts as a “driver” of nutrients and chemicals into the tissues; theobromine could also be responsible for exaggerating the effects of THC, CBD, and even the anandamide found in chocolate.

Special Note on Cannabis Smoking:
Numerous arguments are levied against smoking cannabis including: the illegality of the substance in most nations, short-term memory impairment, influence on the cerebellum that could lead to loss of coordination, potential withdrawal symptoms, and that cannabis smoke contains some carcinogenic substances. However, most of these arguments fall apart when eating, blending, or juicing organic, outdoor-grown cannabis leaves and flowers (which typically delivers a higher ratio of stabilizing CBDs and lower, or even no psychoactive THC effects), when consuming them in chocolate (to amplify and modulate the delivery of cannabinoids) and/or when creating and using their extracts in oil (as, for example, medicinally described in the film “Run From The Cure”).


Reggio, Patricia (editor), “The Cannabinoid Receptors,” (Greensboro, NC), Humana Press, 2009
Wolfe, David (with Shazzie) “Naked Chocolate: The Astonishing Truth About the World’s Greatest Food” (Berkeley, California), North Atlantic Books, 2005
Watson, Ronald Ross, Preedy, Victor R., Zibadi, Sherma, “Chocolate In Health and Nutrition,” New York, Humana Press, 2013


Cannabis Consumers 54% Less Likely To Have Metabolic Syndrome


recent study from the University of Miami has shown that those who partake in cannabis are half as likely to have metabolic syndrome, a condition that puts people at risk for heart attack, diabetes and stroke.

An analysis of almost 8500 people that completed the 2005-2010 National Health and Nutrition Examination Surveys compared markers of metabolic syndrome with cannabis use to find correlations. Metabolic syndrome, a set of risk factors for cardiovascular disease, stroke and diabetes, occurs when a person has three or more of the following: high waist measurement, high triglycerides, low HDL, high blood pressure and high fasting glucose levels.

While 13.8% of current cannabis smokers and 17.5% of past tokers had metabolic syndrome, 19.5% of those who had never touched the stuff did have the condition. Statistically speaking, this makes smokers dabbers and edible cannaseurs 54% less likely to have a condition that can lead to heart disease, diabetes or stroke.






A recent study conducted by researchers at the University of Florida has shown

that alcohol is far more of a “gateway drug” than marijuana is.


Results from the Guttman scale indicated that alcohol represented the “gateway” drug, leading to the use of tobacco, marijuana, and other illicit substances. Moreover, students who used alcohol exhibited a significantly greater likelihood of using both licit and illicit drugs. The findings from this investigation support that alcohol should receive primary attention in school-based substance abuse prevention programming, as the use of other substances could be impacted by delaying or preventing alcohol use. Therefore, it seems prudent for school and public health officials to focus prevention efforts, policies, and monies, on addressing adolescent alcohol use.




Parents find success treating kids’ epilepsy, autism with cannabis oil.

But lack of research, poor industry standards and few doctors willing to prescribe mean parents left to experiment to find consistent dosages.


Mention Taylor Swift and five-year-old Ella’s eyes light up like the Christmas tree in the corner of her Surrey living room.

The tree scrapes the ceiling, and Ella is eager to play with the decorations, but her parents have set up a barricade so she can’t reach the branches.

That’s because the young girl has severe epilepsy and autism, and, although she is nearly six, the cognitive ability of a toddler.

She doesn’t seem to mind, as her attention is soon diverted to a suggestion that she sing a song by Swift, her favourite recording artist.

Yet the strong-willed Ella has other ideas.

“Meatballs,” the bright little girl exclaims, and the family launches into a rousing verse of On Top of Spaghetti.

A year ago, Ella would not have been singing about meatballs, giggling as she sways her hips to Swift, or scribbling in her Dora the Explorer colouring book as she is now.

She would have slept all day, her few precious waking hours spent groggy and depressed because of the medication she takes to control more than a hundred seizures a day.

Ella still takes a cocktail of anti-seizure pills, but her parents, Kim and Rob Turkington, have added two shots per day of marijuana oil, a medicine her parents say has made her more alert, reduced the number and severity of seizures, and allowed her to develop speech and other cognitive functions.

They’re not alone, as more parents, frustrated with failed pharmaceuticals, turn to cannabis oil, ideally one that is low in tetrahydrocannabinol (THC), the psychoactive agent, and high in cannabidiol (CBD), one of hundreds of compounds found in the marijuana plant believed to stop seizures.

The family of Summerland toddler Kyla Williams (an epileptic child who solely relies on CBD oil to stop seizures) has a similar story, as does Simon Fraser University lecturer Sherri Brown.

They share the same caveat: Cannabis is not a miracle drug, but can significantly improve the quality of life for some children.

Like Ella, Brown’s son, five-year-old Quinn Barker-Brown, became much more alert after the family last year began using the same brand Ella takes, called Charlotte’s Web, a strain that has a 28:1 ratio of CBD to THC.

The problem is Charlotte’s Web, considered among parents to be the gold standard in kids’ cannabis, is not available in Canada so they import it from Colorado.

It became legal to buy CBD oil from a licensed producer this summer, after the Supreme Court ruled Canadians have the right to buy derivatives of medical marijuana. However, it wasn’t available until earlier this month when an Ontario company became the first to be allowed to sell cannabis oil by Health Canada.

Many parents still struggle to find a consistent strain low in THC. They buy from unregulated dispensaries, only to find out by trial and error that the product they bought was too high in the psychoactive compound.

No one wants their kids tripping out. That’s why many B.C. parents have in recent months formed a loose network, sharing tips on CBD dosage and which dispensaries offer the most suitable products for children, while they wait for science and law to catch up with demand.







Crazy Health Benefits of Juicing Raw Cannabis


Contrary to popular belief, the marijuana plant is a whole lot more than just a psychoactive drug that “stoners” use to get high.

In raw form, marijuana leaves and buds are actually loaded with a non-psychoactive, antioxidant, anti-inflammatory, and anti-cancer nutrient compound known as cannabidiol (CBD) that is proving to be a miracle “superfood” capable of preventing and reversing a host of chronic illnesses.

The old saying an “apple a day keeps the doctor away” could officially be replaced by “a cup of juiced cannabis a day keeps the doctors away”.

Here is just a very SHORT list of some of the benefits of juicing raw cannabis:

1.  Antioxidants

2. Increased muscle repair

3. Increased quality of immune system which will help you fight off illness both severe and basic.

4. You can ingest higher than usual doses of cannabis this way because there will be little to no psychoactive effects.

Again , this is just a very short list and much more is still to be learned about juicing and consuming raw cannabis.




Is Marijuana an Effective Treatment for Crohn's Disease, Ulcerative Colitis, or Other Inflammatory Bowel Diseases?

General Reference (not clearly pro or con)

The Centers for Disease Control Prevention, an agency of the United States Department of Health and Human Services, provides the following definitions on its website cdc.gov(accessed Mar. 26, 2013):

"Inflammatory Bowel Disease (IBD) - is a broad term that describes conditions with chronic or recurring immune response and inflammation of the gastrointestinal tract. The two most common inflammatory bowel diseases are ulcerative colitis and Crohn’s disease."

"Ulcerative colitis is a chronic gastrointestinal disorder that is limited to the large bowel (the colon)... The first symptom of ulcerative colitis is a progressive loosening of the stool. The stool is generally bloody and may be associated with cramping abdominal pain and severe urgency to have a bowel movement... Loss of appetite and subsequent weight loss are common, as is fatigue."

"Crohn's disease is a condition of chronic inflammation potentially involving any location of the gastrointestinal tract, but it frequently affects the end of the small bowel and the beginning of the large bowel... Symptoms include persistent diarrhea (loose, watery, or frequent bowel movements), cramping abdominal pain, fever, and, at times, rectal bleeding... Two-thirds to three-quarters of patients with Crohn's disease will require surgery at some point during their lives."

Mar. 26, 2013 - Source:



Medical Marijuana Cuts Suicide Rates By 10% In Years Following Legalization


Legalization of medical marijuana has been found to correlate to a significant drop in suicide rates, providing additional evidence that the federally outlawed substance may have a positive effect on U.S. public health.

The new study, which is published in the American Journal of Public Health, shows that the suicide rate among men ages 20 to 29 and 30 to 39 fell by 10.8 percent and 9.8 percent respectively following a given state’s decision to legalize medical marijuana. Although the relationship was weaker and less precise among women, the authors believe that the findings provide strong evidence in favor of medical cannabis. “The negative relationship between legalization and suicides among young men is consistent with the hypothesis that marijuana can be used to cope with stressful life events,” they wrote.

To investigate, the team looked at suicide rates per 100,000 people in a set of states allowing medical marijuana as well as a group of control states in which the drug is still illegal. Using data from the National Vital Statistics System’s Mortality Detail Files, they were able to graph a six-year trend beginning three years before the law change and ending three years after.


The researchers found that, in the years leading up to the new law, the male suicide trend was largely the same across all surveyed states. But as soon as medical marijuana was introduced, state trends began to diverge, with legalizing states recording a drop and non-legalizing states recording a surge. On average, states that legalized the medicinal use of the drug cut the male suicide rate from 27.2 per 100,000 men to 23.5 in the three years following the law change.

“Opponents of legalizing medical marijuana point to the large number of studies showing that marijuana use is positively associated with depression, the onset of panic attacks, psychosis, schizophrenia, and suicidal ideation,” the authors explained. “However, the association between marijuana use and outcomes such as these could be attributable to difficult-to-measure confounders such as personality.”

According to the Mayo Clinic, there is “good scientific evidence” that the medical marijuana can be used as palliative treatment for multiple sclerosis and other conditions involving chronic nerve and muscle pain. That said, success stories from patients suggest that the drug can help alleviate an even broader range of symptoms, including seizures associated with epilepsy. One example is Charlotte Figi, a 6-year-old with epilepsy whose life was transformed by a course of low-THC cannabis oil.





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